These two teams were battling for the title last year and are fighting it out once again, this time with Liverpool in the mix too.
Pep Guardiola will once again take on his old protege Mikel Arteta and he really needs City to come up with a big performance today.
Stefan Ortega starts in goal for City with Ederson still out through injury.
Ruben Dias and Nathan Ake are the centre back pairing with right back Manuel Akanji moving into midfield and left back Josko Gvardiol tucking in to form a back three.
Rodri features in midfield with Mateo Kovacic and Kevin De Bruyne ahead of him, supplying the front three of Bernardo Silva, Phil Foden and Erling Haaland.
John Stones has made a rapid recovery to take a place in the bench, joining Scott Carson, Jack Grealish, Jeremy Doku, Julian Alvarez, Sergio Gomez, Matheus Nunes, Oscar Bobb and Rico Lewis.
Arsenal go with David Raya between the sticks with a familiar centre back pairing ahead of him in William Saliba and Gabriel Magalhaes.
Ben White and Jakub Kiwior are the full backs this afternoon with Jorginho taking on a number six role.
Declan Rice and Martin Odegaard play ahead of Jorginho with Gabriel Jesus coming in for Leandro Trossard on the left flank.
Bukayo Saka starts on the right with Kai Havertz through the middle in the Arsenal attack.
That means Gabriel Martinelli is only on the bench, joining Aaron Ramsdale, Takehiro Tomiyasu, Oleksandr Zinchenko, Thomas Partey, Fabio Vieira, Emile Smith Rowe, Trossard and Eddie Nketiah.
Manchester City starting XI: Ortega; Akanji, Dias, Ake, Gvardiol; Rodri, Kovacic, De Bruyne; Bernardo, Foden, Haaland.
Manchester City substitutes: Carson, Stones, Grealish, Doku, Alvarez, Gomez, Nunes, Bobb, Lewis.
Arsenal starting XI: Raya; White, Saliba, Gabriel, Kiwior; Jorginho, Rice, Odegaard; Saka, Havertz, Jesus.
Arsenal substitutes: Ramsdale, Tomiyasu, Zinchenko, Partey, Vieira, Smith Rowe, Trossard, Martinelli, Nketiah.
